Xeljanz, Twitter, 3/23/2019 7:31:33 AM, 191366


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Xeljanz_2019-03-22_16-13-41.xlsx
Xeljanz_2019-03-22_16-13-41.xlsx
From:
NodeXLExcelAutomator
Uploaded on:
March 23, 2019
Short Description:
Xeljanz via NodeXL http://bit.ly/2U2MEHr
@johncendpts
@ema_news
@pfizer
@lelkens
@nataliegrover
@jonathanyeagley
@john_lamattina
@matthewherper
@danielhsolomon
@medscape

Top hashtags:
#xeljanz
#pharma
#rheumatoidarthritis
#tofacitinib
#fda
#patients

Description:
Description
The graph represents a network of 1,233 Twitter users whose tweets in the requested range contained "Xeljanz", or who were replied to or mentioned in those tweets. The network was obtained from the NodeXL Graph Server on Friday, 22 March 2019 at 23:13 UTC.

The requested start date was Thursday, 21 March 2019 at 00:01 UTC and the maximum number of tweets (going backward in time) was 5,000.

The tweets in the network were tweeted over the 78-day, 21-hour, 55-minute period from Tuesday, 01 January 2019 at 01:02 UTC to Wednesday, 20 March 2019 at 22:57 UTC.

Additional tweets that were mentioned in this data set were also collected from prior time periods. These tweets may expand the complete time period of the data.

There is an edge for each "replies-to" relationship in a tweet, an edge for each "mentions" relationship in a tweet, and a self-loop edge for each tweet that is not a "replies-to" or "mentions".

The graph is directed.

The graph's vertices were grouped by cluster using the Clauset-Newman-Moore cluster algorithm.

The graph was laid out using the Harel-Koren Fast Multiscale layout algorithm.


Author Description


Overall Graph Metrics
Vertices : 1233
Unique Edges : 1187
Edges With Duplicates : 586
Total Edges : 1773
Number of Edge Types : 3
Tweet : 848
Mentions : 757
Replies to : 168
Self-Loops : 848
Reciprocated Vertex Pair Ratio : 0.0361145703611457
Reciprocated Edge Ratio : 0.0697115384615385
Connected Components : 538
Single-Vertex Connected Components : 385
Maximum Vertices in a Connected Component : 204
Maximum Edges in a Connected Component : 325
Maximum Geodesic Distance (Diameter) : 15
Average Geodesic Distance : 5.072217
Graph Density : 0.000547708576905657
Modularity : 0.568125
NodeXL Version : 1.0.1.409

Top Influencers: Top 10 Vertices, Ranked by Betweenness Centrality
Top URLs
Top URLs in Tweet in Entire Graph:
[145] https://www.xeljanz.com
[25] https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/UCM632016
[19] https://www.fiercepharma.com/pharma/fda-alerts-public-to-dosing-risks-for-pfizer-s-xeljanz
[15] https://endpts.com/pfizer-study-drops-10-mg-dose-of-best-selling-xeljanz-as-safety-study-spotlights-cardio-safety-questions-higher-rate-of-deaths/
[14] https://www.fda.gov/Drugs/DrugSafety/ucm631871.htm
[13] https://endpts.com/fda-hits-the-alarm-on-pfizers-blockbuster-xeljanz-after-a-high-dose-was-linked-to-a-higher-death-rate-severe-cardio-risks/
[11] https://endpts.com/pfizers-blockbuster-safety-issue-jumps-the-atlantic-as-ema-launches-its-own-review-of-xeljanz/
[11] https://login.medscape.com/login/sso/getlogin?urlCache=aHR0cHM6Ly93d3cubWVkc2NhcGUuY29tL3ZpZXdhcnRpY2xlLzkwOTU1MT9zcmM9c29jX3R3X3NoYXJl&ac=401
[10] https://www.fiercepharma.com/marketing/does-pfizer-s-xeljanz-share-its-safety-issues-burgeoning-jak-class
[8] https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm632016.htm

Top URLs in Tweet in G1:
[18] https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/UCM632016
[9] https://www.fda.gov/Drugs/DrugSafety/ucm631871.htm
[8] https://www.fiercepharma.com/pharma/fda-alerts-public-to-dosing-risks-for-pfizer-s-xeljanz
[7] https://www.fiercepharma.com/marketing/does-pfizer-s-xeljanz-share-its-safety-issues-burgeoning-jak-class
[5] https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm632016.htm
[4] http://www.pharmatimes.com/news/nice_approves_xeljanz_for_ulcerative_colitis_1273928
[4] https://sarcoidosisnews.com/2019/01/14/xeljanz-successfully-used-treat-disfiguring-sarcoidosis/
[4] https://endpts.com/pfizer-study-drops-10-mg-dose-of-best-selling-xeljanz-as-safety-study-spotlights-cardio-safety-questions-higher-rate-of-deaths/
[4] https://endpts.com/fda-hits-the-alarm-on-pfizers-blockbuster-xeljanz-after-a-high-dose-was-linked-to-a-higher-death-rate-severe-cardio-risks/
[4] https://www.drugs.com/fda/safety-communication-xeljanz-xeljanz-xr-tofacitinib-safety-trial-finds-increased-risk-blood-clots-14247.html?utm_source=ddc&utm_medium=email&utm_campaign=FDA+Alert+-+Safety+Communication%3A+Xeljanz%2C+Xeljanz+XR+%28tofacitinib%29+Safety+Trial+Finds+Increased+Risk+of+Blood+Clots+in+the+Lungs+and+Death+with+Higher+Dose+in+Rheumatoid+Arthritis+Patients

Top URLs in Tweet in G2:
[11] https://endpts.com/pfizer-study-drops-10-mg-dose-of-best-selling-xeljanz-as-safety-study-spotlights-cardio-safety-questions-higher-rate-of-deaths/
[8] https://endpts.com/fda-hits-the-alarm-on-pfizers-blockbuster-xeljanz-after-a-high-dose-was-linked-to-a-higher-death-rate-severe-cardio-risks/
[8] https://www.fiercepharma.com/pharma/fda-alerts-public-to-dosing-risks-for-pfizer-s-xeljanz
[7] https://www.prnewswire.com/news-releases/fda-responds-to-safety-signal-reported-in-required-postmarketing-trial-for-xeljanz-300801561.html
[6] https://endpts.com/fda-cites-an-ongoing-review-for-pfizers-blockbuster-xeljanz-in-wake-of-a-safety-scare/
[6] https://endpts.com/pfizers-blockbuster-safety-issue-jumps-the-atlantic-as-ema-launches-its-own-review-of-xeljanz/
[1] http://www.twitlonger.com/show/n_1sqqi4g
[1] https://endpts.com/?p=207724&preview=true
[1] https://endpts.com/ema-sounds-its-own-safety-alarm-for-pfizer-blockbuster-but-theyre-also-not-forcing-a-limit-on-dosing-yet/
[1] https://www.fiercepharma.com/marketing/does-pfizer-s-xeljanz-share-its-safety-issues-burgeoning-jak-class

Top URLs in Tweet in G4:
[3] https://www.fiercepharma.com/pharma/fda-alerts-public-to-dosing-risks-for-pfizer-s-xeljanz
[3] https://www.fiercepharma.com/marketing/abbvie-humira-holds-for-tv-ad-win-december-edging-pfizer-xeljanz-year-end-push
[2] Daily
[2] Headlines
[2] https://www.medpagetoday.com/rheumatology/arthritis/78224
[1] https://topclassactions.com/lawsuit-settlements/prescription/886441-fda-says-safety-trial-linked-xeljanz-blood-clot-risk/
[1] https://www.pharmacytimes.com/news/fda-officials-report-increased-risk-of-blood-clots-in-lungs-death-with-higher-dose-tofacitinib
[1] https://www.fiercepharma.com/marketing/does-pfizer-s-xeljanz-share-its-safety-issues-burgeoning-jak-class
[1] https://twitter.com/odibro/status/1100148930887725057
[1] https://twitter.com/endpts/status/1101445821797675008

Top URLs in Tweet in G5:
[4] https://emergencydrug.com/drug/tofacitinib-5mg/

Top URLs in Tweet in G6:
[2] https://www.medpagetoday.com/rheumatology/arthritis/78224
[2] https://twitter.com/RA_Guy/status/1104749814250655744
[1] https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/UCM632016
[1] https://twitter.com/Dividivigirl/status/1100865817867096076
[1] https://www.empr.com/home/news/safety-alerts-and-recalls/increased-risk-of-pulmonary-embolism-death-in-ra-patients-reported-in-tofacitinib-postmarketing-study/
[1] https://twitter.com/danielhsolomon/status/1100239497407664128

Top URLs in Tweet in G7:
[1] https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm632016.htm
[1] https://twitter.com/danielhsolomon/status/1100239497407664128
[1] https://www.medscape.com/viewarticle/909551?src=soc_tw_share
[1] https://www.smartbrief.com/branded/8F6EFCB4-452E-479A-9180-62F7A705462A/ADE49174-48D2-4D8C-8ADE-ECA28E869F40

Top URLs in Tweet in G8:
[2] http://www.pharmatimes.com/news/pfizer_adjusts_xeljanz_trial_due_to_pulmonary_embolism_risk_1279030
[1] https://twitter.com/John_LaMattina/status/1093193926230577152
[1] https://www.nytimes.com/2013/03/19/business/questions-for-public-private-pact-that-led-to-xeljanz.html
[1] https://twitter.com/jflier/status/1091171415309643777
[1] https://www.nytimes.com/2013/03/19/business/questions-for-public-private-pact-that-led-to-xeljanz.html?module=inline
[1] http://www.pharmatimes.com/news/nice_approves_xeljanz_for_ulcerative_colitis_1273928

Top URLs in Tweet in G10:
[1] https://www.actasanitaria.com/ema-coagulos-xeljanz/
[1] https://www.ema.europa.eu/en/news/increased-risk-blood-clots-lungs-death-higher-dose-xeljanz-tofacitinib-rheumatoid-arthritis
[1] https://www.firstwordpharma.com/node/1621645
[1] https://www.firstwordpharma.com/node/1626119

Top Domains
Top Domains in Tweet in Entire Graph:
[145] xeljanz.com
[74] fiercepharma.com
[65] fda.gov
[57] endpts.com
[39] medscape.com
[26] twitter.com
[25] pharmatimes.com
[16] dlvr.it
[16] drugs.com
[11] facebook.com

Top Domains in Tweet in G1:
[41] fiercepharma.com
[40] fda.gov
[17] pharmatimes.com
[15] endpts.com
[13] dlvr.it
[12] medscape.com
[11] facebook.com
[11] drugs.com
[10] twitter.com
[5] sarcoidosisnews.com

Top Domains in Tweet in G2:
[33] endpts.com
[9] fiercepharma.com
[7] prnewswire.com
[1] twitlonger.com
[1] twitter.com
[1] dlvr.it

Top Domains in Tweet in G4:
[10] fiercepharma.com
[5] pharmatimes.com
[3] medpagetoday.com
[2] twitter.com
[2] raps.org
[2] thepharmaletter.com
[1] topclassactions.com
[1] pharmacytimes.com
[1] iex.nl
[1] fda.gov

Top Domains in Tweet in G5:
[4] emergencydrug.com

Top Domains in Tweet in G6:
[4] twitter.com
[2] medpagetoday.com
[1] fda.gov
[1] empr.com

Top Domains in Tweet in G7:
[1] fda.gov
[1] twitter.com
[1] medscape.com
[1] smartbrief.com

Top Domains in Tweet in G8:
[3] pharmatimes.com
[2] twitter.com
[2] nytimes.com

Top Domains in Tweet in G10:
[2] firstwordpharma.com
[1] actasanitaria.com
[1] europa.eu

Top Hashtags
Top Hashtags in Tweet in Entire Graph:
[116] xeljanz
[37] pharma
[27] rheumatoidarthritis
[26] tofacitinib
[23] fda
[16] patients
[13] psoriaticarthritis
[12] ojoaldato
[11] biotech
[10] ulcerativecolitis



Top Hashtags in Tweet in G1:
[39] xeljanz
[17] pharma
[7] fda
[6] tofacitinib
[5] pfizer
[5] rheumatoidarthritis
[5] pharmacovigilance
[5] regulatory
[4] humira
[3] arthritis

Top Hashtags in Tweet in G2:
[10] xeljanz
[6] fda
[2] ema
[2] biotech
[2] biopharma
[2] pharma
[1] patients
[1] cardiovascular
[1] biologics

Top Hashtags in Tweet in G4:
[10] xeljanz
[4] tofacitinib
[4] pharma
[3] trial
[3] humira
[3] regulatory
[2] blood
[2] arthritis
[2] filgotinib
[2] ad

Top Hashtags in Tweet in G5:
[1] tofacent
[1] tofacitinib
[1] xeljanz
[1] rheumatoidarthritis
[1] psoriaticarthritis
[1] ulcerativecolitis

Top Hashtags in Tweet in G6:
[5] rheum
[2] rheumatology
[2] rheumedu
[2] spoonies
[2] chronicillness
[2] xeljanz
[1] arthritis
[1] oluminant

Top Hashtags in Tweet in G7:
[12] ojoaldato
[5] jakacademy

Top Hashtags in Tweet in G8:
[2] news
[2] lifesciences
[1] xeljanz
[1] colitis

Top Hashtags in Tweet in G10:
[13] patients
[13] xeljanz
[1] rheumatoidarthritis
[1] arthritis

Top Words
Top Words in Tweet in Entire Graph:
[724] Words in Sentiment List#1: Positive
[1143] Words in Sentiment List#2: Negative
[9] Words in Sentiment List#3: Angry/Violent
[31702] Non-categorized Words
[33570] Total Words
[1553] xeljanz
[376] safety
[298] dose
[284] pfizer
[275] fda

Top Words in Tweet in G1:
[577] xeljanz
[157] safety
[132] dose
[103] death
[100] tofacitinib
[98] higher
[96] risk
[91] patients
[88] blood
[87] xr

Top Words in Tweet in G2:
[126] xeljanz
[73] pfe
[60] johncendpts
[59] pfizer
[53] dose
[48] fda
[47] s
[46] rate
[42] higher
[39] safety

Top Words in Tweet in G3:
[51] xeljanz
[50] mileskahn
[50] prescription
[50] drugs
[50] sound
[50] focalin
[50] focus
[50] lipitor
[50] lipids
[50] tofranil

Top Words in Tweet in G4:
[47] xeljanz
[22] safety
[21] pfizer
[15] glpg
[14] fda
[13] met
[12] us_fda
[11] dose
[11] tofacitinib
[11] galapagos

Top Words in Tweet in G5:
[25] xeljanz
[19] 000
[16] year
[13] canada
[9] jonathanyeagley
[9] buy
[9] costs
[8] 15
[6] cost
[6] more

Top Words in Tweet in G6:
[71] xeljanz
[23] patients
[21] xr
[21] fda
[20] ra_guy
[20] s
[20] rheumatologist
[19] alerting
[19] health
[19] care

Top Words in Tweet in G7:
[44] xeljanz
[36] safety
[24] tofacitinib
[12] alerts
[12] human
[12] medical
[12] products
[12] gt
[12] xr
[12] communication

Top Words in Tweet in G8:
[24] xeljanz
[21] those
[21] caught
[21] up
[21] debate
[21] drugs
[21] discovered
[21] story
[21] tofacitinib
[21] great

Top Words in Tweet in G9:
[24] receipt
[23] friend
[23] showed
[23] pharma
[23] pickup
[23] walgreens
[23] printed
[23] advertisement
[23] xeljanz
[23] 5

Top Words in Tweet in G10:
[26] xeljanz
[21] tofacitinib
[15] dose
[14] patients
[13] ema_news
[13] ema
[13] advising
[13] healthcare
[13] professionals
[13] exceed

Top Word Pairs
Top Word Pairs in Tweet in Entire Graph:
[165] xeljanz,xr
[152] higher,dose
[146] ask,doctor
[143] xeljanz,xeljanz
[135] blood,clots
[133] call,1
[133] 1,844
[121] doctor,more
[115] more,information
[115] information,call

Top Word Pairs in Tweet in G1:
[85] higher,dose
[84] xeljanz,xr
[82] blood,clots
[69] clots,lungs
[68] lungs,death
[66] rheumatoid,arthritis
[65] death,higher
[64] risk,blood
[64] xeljanz,xeljanz
[59] trial,finds

Top Word Pairs in Tweet in G2:
[40] pfizer,s
[39] s,blockbuster
[30] blockbuster,xeljanz
[23] 10,mg
[22] safety,issue
[21] sorry,here's
[21] here's,right
[21] right,link
[21] link,pfe
[21] pfe,story

Top Word Pairs in Tweet in G3:
[50] prescription,drugs
[50] drugs,sound
[50] sound,focalin
[50] focalin,focus
[50] focus,lipitor
[50] lipitor,lipids
[50] lipids,tofranil
[50] tofranil,tof
[50] tof,nails
[50] nails,xeljanz

Top Word Pairs in Tweet in G4:
[9] safety,issues
[7] 10,mg
[7] met,xeljanz
[7] xeljanz,tofacitinib
[6] issues,met
[5] galapagos,fda
[5] fda,reageert
[5] reageert,nu
[5] nu,zelf
[5] zelf,persbericht

Top Word Pairs in Tweet in G5:
[15] 000,year
[8] 15,000
[7] canada,buy
[7] buy,xeljanz
[6] supply,xeljanz
[6] pcmanet,go
[6] go,canada
[6] xeljanz,15
[6] year,costs
[6] costs,52

Top Word Pairs in Tweet in G6:
[21] xeljanz,xr
[20] xeljanz,xeljanz
[19] fda,alerting
[19] alerting,patients
[19] patients,health
[19] health,care
[19] care,professionals
[19] professionals,pharmacists
[19] pharmacists,rheumatologist
[19] rheumatologist,pfizer

Top Word Pairs in Tweet in G7:
[12] safety,alerts
[12] alerts,human
[12] human,medical
[12] medical,products
[12] products,gt
[12] gt,xeljanz
[12] xeljanz,xeljanz
[12] xeljanz,xr
[12] xr,tofacitinib
[12] tofacitinib,safety

Top Word Pairs in Tweet in G8:
[21] those,caught
[21] caught,up
[21] up,debate
[21] debate,drugs
[21] drugs,discovered
[21] discovered,story
[21] story,tofacitinib
[21] tofacitinib,xeljanz
[21] xeljanz,great
[20] john_lamattina,those

Top Word Pairs in Tweet in G9:
[23] friend,showed
[23] showed,pharma
[23] pharma,pickup
[23] pickup,receipt
[23] receipt,walgreens
[23] walgreens,printed
[23] printed,advertisement
[23] advertisement,xeljanz
[23] xeljanz,5
[23] 5,000

Top Word Pairs in Tweet in G10:
[13] ema,advising
[13] advising,healthcare
[13] healthcare,professionals
[13] professionals,patients
[13] patients,exceed
[13] exceed,recommended
[13] recommended,dose
[13] dose,xeljanz
[13] xeljanz,tofacitinib
[12] ema_news,ema

Top Replied-To
Top Replied-To in Entire Graph:
@cadria04
@rheumerhasit
@realdonaldtrump
@cbsnews
@smckays
@southerncynic
@121kath
@ra_guy
@alinnzy
@molly__pepper

Top Replied-To in G2:
@daawjoons

Top Replied-To in G3:
@mileskahn

Top Replied-To in G4:
@pfizer
@cw_arrow
@lama_daila
@lelkens

Top Replied-To in G5:
@realdonaldtrump
@jonathanyeagley
@secazar
@davidp4ad
@whitehouse
@cheleshine
@bevih2o
@vincentrk
@pcmanet
@eugenegu

Top Replied-To in G6:
@rheumerhasit
@121kath
@alinnzy
@ra_guy
@ginarclark
@notoriouscmoney
@hurtblogger
@dividivigirl
@shopshi
@kitcatlady9

Top Mentioned
Top Mentioned in Entire Graph:
@johncendpts
@mileskahn
@crulge
@john_lamattina
@ra_guy
@medscape
@ema_news
@_timos_
@soler_kike
@us_fda

Top Mentioned in G1:
@arthritis_bio
@novartis_bio
@pfizer_bio
@food_safety
@cmencke
@rheumatic_bio
@drfreiheit254
@discoverydrug
@clinicalphase

Top Mentioned in G2:
@johncendpts
@andybiotech
@cmichaelgibson
@odibro
@jebkeiper
@endpts
@sgottliebfda
@_b_i_o_t_e_c_h_
@ema_news
@nimbustx

Top Mentioned in G3:
@mileskahn
@mollyjongfast

Top Mentioned in G4:
@us_fda
@pfizer
@lama_daila
@floszcrxl
@nicecomms
@pfizer_news
@galapagosnv
@fiercepharma
@pharmacy_times
@ema_news

Top Mentioned in G5:
@jonathanyeagley
@pcmanet
@mayoclinic
@aslavitt
@policydeb
@leighdrugwonk
@haroldpollack
@besables
@berector
@loftus

Top Mentioned in G6:
@ra_guy
@dividivigirl
@lcyoung65
@denisenolson
@alinnzy
@tracinnasv
@shopshi
@sirhayofwood
@catheri58232231

Top Mentioned in G7:
@carvicab
@danielhsolomon
@etrujillomartin
@reumastat
@medscape

Top Mentioned in G8:
@john_lamattina
@jflier
@pharmatimes
@dereklowe
@matthewherper
@aoc

Top Mentioned in G9:
@crulge

Top Mentioned in G10:
@ema_news
@physns1stwatch
@fwpharma
@andybiotech

Top Tweeters
Top Tweeters in Entire Graph:
@follementbijoux
@politicalhedge
@razzletazzlemag
@israelnewslinks
@liveedges
@fn_news_en
@kimvie
@business
@tvthirdeye
@drpatfarrell

Top Tweeters in G1:
@follementbijoux
@politicalhedge
@razzletazzlemag
@israelnewslinks
@liveedges
@fn_news_en
@tvthirdeye
@drpatfarrell
@hedgebz
@quoteallthethin

Top Tweeters in G2:
@paynej247
@815wrldtrvlr
@bioportfolio
@jhcpw
@mogulazam
@_01katarina
@ruthhalleran
@donnayoungdc
@johnnosta
@portefeuillefun

Top Tweeters in G3:
@greytdog
@mostlymartha
@jonrosenberg
@mollyjongfast
@alanpdx
@mrjoncryer
@cobalt_octopus
@mrdankelly
@whyyesitsaj
@robertreyes

Top Tweeters in G4:
@kimvie
@gma
@medpagetoday
@topclassactions
@fiercepharma
@pharmacy_times
@rapsorg
@beurstweet
@lillypad
@ammiano13

Top Tweeters in G5:
@demgirl50
@cathrynlsmith1
@haroldpollack
@melinda15858273
@misterchambo
@mayoclinic
@realdonaldtrump
@margaret_sc
@thebloggess
@aslavitt

Top Tweeters in G6:
@justmemarie2
@dawnmgibson
@thebaddestnuna
@shopshi
@medwaygirl74
@sfdegraff
@hurtblogger
@121kath
@farfbaz
@suzer46

Top Tweeters in G7:
@davipc19
@sjogrensforum
@carvicab
@harrygewanter
@noticias_reuma
@onatevalle
@yurilisjfuentes
@reumastat
@kevinmb01
@jc_gonzal

Top Tweeters in G8:
@youngchris27040
@palecur
@educate_tv
@lteytelman
@afternoonnapper
@mahmissa
@giraudsylvain
@cispt2
@jflier
@pharmatimes

Top Tweeters in G9:
@ninma_
@makarov__
@sandhralee
@panndder
@people4bernie
@catherinebuca
@tinybird420
@crulge
@judithpriest007
@becomeboundless

Top Tweeters in G10:
@parreshia
@actasanitaria
@realmaciej
@fwpharma
@johnrod76512584
@ema_news
@physns1stwatch
@antonioemarrero
@bmulkeymd
@anitamulero


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